NEW INSIGHTS INTO T-CELL ANTIGEN RECEPTOR STRUCTURE AND SIGNAL TRANSDUCTION

被引：43

作者：

CHAN, AC ^{[1
]}

IRVING, BA ^{[1
]}

WEISS, A ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO,HOWARD HUGHES MED INST,BOX 0724,3RD & PARNASSUS AVE,SAN FRANCISCO,CA 94143

来源：

CURRENT OPINION IN IMMUNOLOGY | 1992年 / 4卷 / 03期

关键词：

D O I：

10.1016/0952-7915(92)90072-M

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent studies have provided insights into how the complex structure of the T-cell antigen receptor relates to its signal transduction function. Both the CD3 and zeta-subunits contain functioning signaling modules that regulate the activation of tyrosine kinases and phosphorylation of cellular substrates.

引用

页码：246 / 251

页数：6

共 36 条

[1] ENHANCEMENT OF T-CELL RESPONSIVENESS BY THE LYMPHOCYTE-SPECIFIC TYROSINE PROTEIN-KINASE P56LCK
ABRAHAM, N
MICELI, MC
PARNES, JR
VEILLETTE, A
[J]. NATURE, 1991, 350 (6313) : 62 - 66
[2] THE CD3-GAMMA AND CD3-DELTA SUBUNITS OF THE T-CELL ANTIGEN RECEPTOR CAN BE EXPRESSED WITHIN DISTINCT FUNCTIONAL TCR/CD3 COMPLEXES
ALARCON, B
LEY, SC
SANCHEZMADRID, F
BLUMBERG, RS
JU, ST
FRESNO, M
TERHORST, C
[J]. EMBO JOURNAL, 1991, 10 (04) : 903 - 912
[3] DIFFERENTIAL SIGNAL TRANSDUCTION VIA T-CELL RECEPTOR CD3-ZETA-2, CD3-ZETA-ETA, AND CD3-ETA-2 ISOFORMS
BAUER, A
MCCONKEY, DJ
HOWARD, FD
CLAYTON, LK
NOVICK, D
KOYASU, S
REINHERZ, EL
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (09) : 3842 - 3846
[4] BIRGESS KE, 1991, EUR J IMMUNOL, V21, P1663
[5] STRUCTURE OF THE T-CELL ANTIGEN RECEPTOR - EVIDENCE FOR 2 CD3 EPSILON-SUBUNITS IN THE T-CELL RECEPTOR CD3 COMPLEX
BLUMBERG, RS
LEY, S
SANCHO, J
LONBERG, N
LACY, E
MCDERMOTT, F
SCHAD, V
GREENSTEIN, JL
TERHORST, C
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (18) : 7220 - 7224
[6] CARSON GR, 1991, J BIOL CHEM, V266, P7883
[7] THE ZETA-CHAIN IS ASSOCIATED WITH A TYROSINE KINASE AND UPON T-CELL ANTIGEN RECEPTOR STIMULATION ASSOCIATES WITH ZAP-70, A 70-KDA TYROSINE PHOSPHOPROTEIN
CHAN, AC
IRVING, BA
FRASER, JD
WEISS, A
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (20) : 9166 - 9170
[8] REGULATION OF T-CELL RECEPTOR SIGNALING BY A SRC FAMILY PROTEIN-TYROSINE KINASE (P59FYN)
COOKE, MP
ABRAHAM, KM
FORBUSH, KA
PERLMUTTER, RM
[J]. CELL, 1991, 65 (02) : 281 - 291
[9] PHOSPHOLIPASE-C-GAMMA-1 ASSOCIATION WITH CD3 STRUCTURE IN T-CELLS
DASGUPTA, JD
GRANJA, C
DRUKER, B
LIN, LL
YUNIS, EJ
RELIAS, V
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 175 (01) : 285 - 288
[10] STRUCTURAL MUTATIONS OF THE T-CELL RECEPTOR ZETA-CHAIN AND ITS ROLE IN T-CELL ACTIVATION
FRANK, SJ
NIKLINSKA, BB
ORLOFF, DG
MERCEP, M
ASHWELL, JD
KLAUSNER, RD
[J]. SCIENCE, 1990, 249 (4965) : 174 - 177

← 1 2 3 4 →