ASSESSMENT OF THE WHEAL SIZE AND SKIN BLOOD-FLOW OF THE ERYTHEMA INDUCED BY HISTAMINE AND ITS MODIFICATION WITH CETIRIZINE AND EBASTINE - A CROSSOVER, DOUBLE-BLIND-STUDY

被引:13
作者
DELACUADRA, J [1 ]
TERUEL, M [1 ]
TEIXIDO, P [1 ]
ROMA, J [1 ]
机构
[1] PRODESFARMA,DEPT CLIN DEV,BARCELONA,SPAIN
关键词
HISTAMINE; CETIRIZINE; EBASTINE; LASER DOPPLER;
D O I
10.1159/000247117
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
In order to assess the antihistaminic power of cetirizine and ebastine, we designed a randomized, double-blind, crossover study, measuring their capacity to modify skin blood flow induced by a histamine prick test. The vasomotor response was compared using a laser Doppler flowmeter. Two hours after intake of the antihistaminic drug, there were significant differences between both drugs. at 4 h, the antihistaminic effect of cetirizine persists, whereas ebastine only showed moderate activity. The reduction of the cutaneous blood flow values (CBFV) showed good activity in both groups, but cetirizine was more potent and showed faster activity than ebastine.
引用
收藏
页码:131 / 134
页数:4
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