FORMULATION OPTIMIZATION OF A HYDROCOLLOID DRESSING

被引：5

作者：

NANGIA, A

LAM, F

HUNG, CT

机构：

[1] UNIV OTAGO, DEPT PHARM, DUNEDIN, NEW ZEALAND

[2] UNIV OTAGO, DEPT MATH & STAT, DUNEDIN, NEW ZEALAND

[3] ZENITH TECHNOL CO LTD, DUNEDIN, NEW ZEALAND

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1990年 / 16卷 / 14期

关键词：

D O I：

10.3109/03639049009023643

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A methodology of mixture experiments has been applied to the formulation of a multicomponent hydrocolloid dressing. Using an extreme vertices statistical design, a semi-occlusive dressing composed of dextran, phospholipid, glycerol and sodium lauryl sulphate has been formulated, which checks evaporative water loss (EWL) from the excised wound surface of rats to an optimum level. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

收藏

页码：2109 / 2123

页数：15

相关论文

共 48 条

[1]

AKITOSHI Y, 1985, CHEM PHARM BULL, V33, P4536

[2] A CONCENTRATION GRADIENT OF BACTERIA WITHIN WOUND TISSUES AND SCAB [J].

BARNETT, A ;

DAVE, B ;

KSANDER, GA ;

VISTNES, LM .

JOURNAL OF SURGICAL RESEARCH, 1986, 41 (03) :326-332

[3] COMPARISON OF SYNTHETIC ADHESIVE MOISTURE VAPOR PERMEABLE AND FINE MESH GAUZE DRESSINGS FOR SPLIT-THICKNESS SKIN-GRAFT DONOR SITES [J].

BARNETT, A ;

BERKOWITZ, RL ;

MILLS, R ;

VISTNES, LM .

AMERICAN JOURNAL OF SURGERY, 1983, 145 (03) :379-381

[4] OPTIMIZATION OF SOLVENT COMPOSITION FOR HIGH-PERFORMANCE THIN-LAYER CHROMATOGRAPHY [J].

BAYNE, CK ;

MA, CY .

JOURNAL OF LIQUID CHROMATOGRAPHY, 1987, 10 (16) :3529-3546

[5] STATISTICAL TECHNIQUES APPLIED TO SOLUBILITY PREDICTIONS AND PHARMACEUTICAL FORMULATIONS - AN APPROACH TO PROBLEM-SOLVING USING MIXTURE RESPONSE-SURFACE METHODOLOGY [J].

BELLOTO, RJ ;

DEAN, AM ;

MOUSTAFA, MA ;

MOLOKHIA, AM ;

GOUDA, MW ;

SOKOLOSKI, TD .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1985, 23 (02) :195-207

[6]

BIRKE GUNNAR, 1965, ACTA MED SCAND, V178, P337

[7]

CORNELL JA, 1981, EXPT MIXTURES DESIGN

[8]

DAVIES JWL, 1982, PHYSL RESPONSES BURN

[9] DETERMINATION OF THE SENSITIVITY OF A TABLET FORMULATION TO VARIATIONS IN EXCIPIENT LEVELS AND PROCESSING CONDITIONS USING OPTIMIZATION TECHNIQUES [J].

DICK, CF ;

KLASSEN, RA ;

AMIDON, GE .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1987, 38 (1-3) :23-31

[10] MATHEMATICAL-MODEL FOR ENTERIC FILM COATING OF TABLETS [J].

DINCER, S ;

OZDURMUS, S .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1977, 66 (08) :1070-1073

← 1 2 3 4 5 →