EPITOPE SPECIFICITY, ANTIBODY-DEPENDENT CELLULAR CYTOTOXICITY, AND NEUTRALIZING ACTIVITY OF ANTIBODIES TO HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 IN AUTOIMMUNE MRL/LPR MICE

被引:10
作者
LOMBARDI, V
PLACIDO, R
SCARLATTI, G
ROMITI, ML
MATTEI, M
MARIANI, F
POCCIA, F
ROSSI, P
COLIZZI, V
机构
[1] UNIV ROMA TOR VERGATA,DEPT BIOL,VIA RIC SCI,I-00133 ROME,ITALY
[2] UNIV ROMA TOR VERGATA,DEPT PEDIAT,ROME,ITALY
[3] UNIV ROMA TOR VERGATA,DEPT HAEMATOL,ROME,ITALY
[4] CAVE TECH ANIM BREEDING UNIT,ROME,ITALY
[5] KAROLINSKA INST,DEPT VIROL,S-10401 STOCKHOLM 60,SWEDEN
关键词
D O I
10.1093/infdis/167.6.1267
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The specificity and functional activity of antibodies to human immunodeficiency virus (HIV) in the sera of MRL/lpr mice were analyzed by peptide-ELISA, antibody-dependent cellular cytotoxicity, and virus neutralization. The specificity of the antibodies in the sera of autoimmune MRL/lpr mice was similar to that of HIV-infected persons; the mouse sera specifically recognized the V3 loop of gp120 and immunodominant regions of gp41 and p24. Moreover, such binding was inhibited both by human HIV-positive sera and by soluble peptides in competition experiments. MRL/lpr sera displayed anti-HIV antibody-dependent cellular cytotoxicity using human peripheral blood lymphocytes as effector cells and HIV-infected H9 cells. Furthermore, the fact that MRL/lpr sera neutralized in vitro infectious HIV (both strains IIIB and MN) suggests these antibodies recognize viral epitopes on the membrane of infected T cells.
引用
收藏
页码:1267 / 1273
页数:7
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