2-AMINO-2-OXAZOLINES .5. SYNTHESIS OF SOME 5-DIALKYLAMINOMETHYL-2-AMINO-2-OXAZOLINES AND EVALUATION OF THEIR DIURETIC ACTIVITY

被引：4

作者：

DEMOTESMAINARD, F

TRANCHOT, J

CAMBAR, J

JARRY, C

机构：

[1] UNIV BORDEAUX 2,ETUD PHYSIOL & PHYSIOPATHOL RENALES GRP,F-33076 BORDEAUX,FRANCE

[2] UNIV BORDEAUX 2,CHIM PHYS LAB,F-33076 BORDEAUX,FRANCE

来源：

ARCHIV DER PHARMAZIE | 1992年 / 325卷 / 04期

关键词：

D O I：

10.1002/ardp.19923250402

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 5-dialkylaminomethyl-2-amino-2-oxazolines was prepared and screened for diuretic activity. These compounds were previously examined for their lipophilic behaviour using a reversed-phase HPLC technique. The capacity factors, expressed as log k'w, were correlated with the partition coefficient log P. A QSAR analysis of the diuretic activity in relation with the lipophilicity was attempted for these structurally related compounds.

引用

页码：193 / 198

页数：6

共 14 条

[1] 2-AMINO-2-OXAZOLINES .2. REACTIVITY OF THE NITROGENS - CRYSTAL-STRUCTURES OF 2 ENDO EXO N-SUBSTITUTED COMPOUNDS
BOSC, JJ
FORFAR, I
JARRY, C
OUHABI, J
LEGER, JM
CARPY, A
[J]. ARCHIV DER PHARMAZIE, 1990, 323 (09) : 561 - 566
[2] BOURIN M, 1988, ARZNEIMITTEL-FORSCH, V38-1, P666
[3] DETERMINATION OF HYDROPHOBIC PARAMETERS BY REVERSED-PHASE LIQUID-CHROMATOGRAPHY - THEORY, EXPERIMENTAL-TECHNIQUES, AND APPLICATION IN STUDIES ON QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS
BRAUMANN, T
[J]. JOURNAL OF CHROMATOGRAPHY, 1986, 373 (02): : 191 - 225
[4] BROTO P, 1984, EUR J MED CHEM, V19, P71
[5] CRAGOE EJ, 1983, DIURETICS CHEM PHARM, P345
[6] RP-HPLC RETENTION DATA OF NEW 2-AMINO-2-OXAZOLINES - AN APPROACH OF THEIR LIPOPHILIC PROPERTIES
DEMOTESMAINARD, F
JARRY, C
THOMAS, J
DALLET, P
[J]. JOURNAL OF LIQUID CHROMATOGRAPHY, 1991, 14 (04): : 795 - 805
[7] DESMOULIERE A, 1983, B SOC PHARM BORDEAUX, V122, P107
[8] RHO-SIGMA-PI ANALYSIS . METHOD FOR CORRELATION OF BIOLOGICAL ACTIVITY + CHEMICAL STRUCTURE
HANSCH, C
FUJITA, T
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1964, 86 (08) : 1616 - &
[9] JARRY C, 1986, EUR J MED CHEM, V21, P138
[10] 2-AMINOOXAZOLINES .1. CRYSTAL AND MOLECULAR-STRUCTURE OF 5-(1-ARYL-4-PIPERAZINO)METHYL-SUBSTITUTED DERIVATIVES WITH ANTIDEPRESSANT ACTIVITY
JARRY, C
BOSC, JJ
OUHABI, J
CARPY, A
[J]. ARCHIV DER PHARMAZIE, 1990, 323 (03) : 157 - 161

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