BUPROPION OVERDOSE AND SEIZURE

被引:26
作者
STORROW, AB [1 ]
机构
[1] JOINT MIL MED CTR,DEPT EMERGENCY MED,LACKLAND AFB,TX
关键词
BUPROPION; OVERDOSE; SEIZURE;
D O I
10.1016/0735-6757(94)90243-7
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
There is little experience with overdose of the relatively new antidepressant bupropion. The case of an 18-year-old healthy adult female patient after an intentional ingestion of 9 g of bupropion is presented. Her hospital course was significant for grand mal seizures, sinus tachycardia without conduction abnormality, and complete neurological recovery. The first pure bupropion overdose in the emergency medicine literature is presented, and the literature pertinent to emergent management of this new antidepressant is reviewed. © 1994.
引用
收藏
页码:183 / 184
页数:2
相关论文
共 18 条
  • [11] Jackson, Head, Kellner, Catatonia associated with bupropion treatment, J Clin Psychol, 53, (1992)
  • [12] Ames, Wirshing, Szuba, Organic mental disorders associated with bupropion in three patients, J Clin Psychol, 53, pp. 53-55, (1992)
  • [13] Preskorn, Antidepressant response and plasma concentrations of bupropion, J Clin Psychol, 44, pp. 137-139, (1983)
  • [14] Findlay, Van Wyck Fleet, Smith, Et al., Pharmacokinetics of bupropion, a novel antidepressant agent, following oral administration to healthy subjects, European Journal of Clinical Pharmacology, 21, pp. 127-135, (1981)
  • [15] Smith, Hinton, Fleck, Et al., Metabolism and excretion of <sup>14</sup>C-bupropion Hcl in humans, Fed Proc, 40, (1981)
  • [16] Nicotra, Rivera, Pool, Et al., Tricyclic Antidepressant Overdose: Clinical and Pharmacologic Observations, Clinical Toxicology, 18, pp. 599-613, (1981)
  • [17] Boehnert, Lovejoy, Value of the QRS Duration versus the Serum Drug Level in Predicting Seizures and Ventricular Arrhythmias after an Acute Overdose of Tricyclic Antidepressants, New England Journal of Medicine, 313, pp. 474-479, (1985)
  • [18] Biggs, Spiker, Petit, Et al., Tricyclic Antidepressant Overdose, JAMA, 238, pp. 135-138, (1977)