THE GLYCINE-RICH SEQUENCE OF PROTEIN-KINASES - A MULTIFUNCTIONAL ELEMENT

被引：154

作者：

BOSSEMEYER, D

机构：

[1] D. Bossemeyer is at the German Cancer Research Centre, Department of Pathochemistry and Molecular Biology of Mitosis, D-69120 Heidelberg

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1994年 / 19卷 / 05期

关键词：

D O I：

10.1016/0968-0004(94)90022-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Evolution favours the use of glycine-rich loops for nucleotide binding in proteins. In the large family of protein kinases, the catalytic domain of which has one of the highest degrees of conservation among all known proteins, the structure of the nucleotide-binding site differs from classical folds. We are now beginning to understand the multiple functional roles of the glycine-rich sequence in protein kinases and some of the structural constraints leading to its conservation.

引用

页码：201 / 205

页数：5

共 36 条

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