PHYSICAL LINKAGE OF THE GENE-CLUSTER CONTAINING THE LCAT GENE TO THE DNA MARKER D16S124 AT HUMAN-CHROMOSOME REGION 16Q22.1

被引：6

作者：

FRENGEN, E ^{[1
]}

BREDE, G ^{[1
]}

LARSEN, F ^{[1
]}

SKRETTING, G ^{[1
]}

PRYDZ, H ^{[1
]}

机构：

[1] UNIV OSLO,CTR BIOTECHNOL,N-0317 OSLO,NORWAY

来源：

CYTOGENETICS AND CELL GENETICS | 1995年 / 68卷 / 3-4期

关键词：

D O I：

10.1159/000133912

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Pulsed-field gel electrophoresis has been used to construct a long-range restriction map spanning more than 900 kb in the q22.1 region of human chromosome 16. The gene cluster containing the lecithin:cholesterol acyl transferase (LCAT) gene is located less than 480 kb from the anonymous DNA marker D16S124 in this map. The results suggest three putative CpG islands within 125 kb, in addition to the island previously shown to be located within the gene cluster. This implies a clustering of both genes and CpG islands in this chromosomal region.

引用

页码：194 / 196

页数：3

共 16 条

[1]

BICKMORE W, 1992, TECHNIQUES ANAL COMP

[2]

BICKMORE WA, 1992, METHOD ENZYMOL, V216, P224

[3] MAMMALIAN CHROMOSOME-BANDING - AN EXPRESSION OF GENOME ORGANIZATION [J].

BICKMORE, WA ;

SUMNER, AT .

TRENDS IN GENETICS, 1989, 5 (05) :144-148

[4] HIGH-RESOLUTION CYTOGENETIC-BASED PHYSICAL MAP OF HUMAN CHROMOSOME-16 [J].

CALLEN, DF ;

DOGGETT, NA ;

STALLINGS, RL ;

CHEN, LZ ;

WHITMORE, SA ;

LANE, SA ;

NANCARROW, JK ;

APOSTOLOU, S ;

THOMPSON, AD ;

LAPSYS, NM ;

EYRE, HJ ;

BAKER, EG ;

SHEN, Y ;

HOLMAN, K ;

PHILLIPS, H ;

RICHARDS, RI ;

SUTHERLAND, GR .

GENOMICS, 1992, 13 (04) :1178-1185

[5] GENOMIC SEQUENCING [J].

CHURCH, GM ;

GILBERT, W .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (07) :1991-1995

[6]

FEINBERG AP, 1984, ANAL BIOCHEM, V137, P266

[7]

HYLAND VJ, 1989, AM J HUM GENET, V42, P373

[8] A TIGHT CLUSTER OF 5 UNRELATED HUMAN GENES ON CHROMOSOME-16Q22.1 [J].

LARSEN, F ;

SOLHEIM, J ;

KRISTENSEN, T ;

KOLSTO, AB ;

PRYDZ, H .

HUMAN MOLECULAR GENETICS, 1993, 2 (10) :1589-1595

[9] CHOICE OF ENZYMES FOR MAPPING BASED ON CPG ISLANDS IN THE HUMAN GENOME [J].

LARSEN, F ;

GUNDERSEN, G ;

PRYDZ, H .

GENETIC ANALYSIS-BIOMOLECULAR ENGINEERING, 1992, 9 (03) :80-85

[10] CPG ISLANDS AS GENE MARKERS IN THE HUMAN GENOME [J].

LARSEN, F ;

GUNDERSEN, G ;

LOPEZ, R ;

PRYDZ, H .

GENOMICS, 1992, 13 (04) :1095-1107

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