PARADOXICAL EFFECT OF HYPOTHERMIA ON SURVIVAL OF LESIONED AND UNINJURED MAMMALIAN SPINAL NEURONS

被引：12

作者：

LUCAS, JH ^{[1
]}

GUO, FW ^{[1
]}

GROSS, GW ^{[1
]}

机构：

[1] UNIV N TEXAS,CTR NETWORK NEUROSCI,DENTON,TX 76203

来源：

BRAIN RESEARCH | 1990年 / 517卷 / 1-2期

关键词：

Cell death; Injury; Ketamine; N-Methyl-d-aspartate; Spinal cord; Swelling; Temperature; Tissue culture;

D O I：

10.1016/0006-8993(90)91051-H

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Survival of cultured spinal neurons 2 h after dendrotomy increased significantly when the temperature was reduced 17 °C or 17 °C. Survival of lesioned neurons maintained at 17 °C for 2 h and then at 37 °C for 22 h was still significantly higher than survival of neurons maintained at 37 °C for 24 h. Below 17 °C both lesioned and uninjured neurons swelled. Upon rewarming to 37 °C, many swollen neurons died. Ketamine prevented hypothermic swelling and neuronal death. © 1990.

引用

页码：354 / 357

页数：4

共 31 条

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