SYNTHESIS OF RACEMIC 2-PHOSPHONOMETHYL-1,3-DIOXOLANE NUCLEOSIDE ANALOGS AS POTENTIAL ANTIVIRAL AGENTS

被引：9

作者：

BEDNARSKI, K

DIXIT, DM

MANSOUR, TS

COLMAN, SG

WALCOTT, SM

ASHMAN, C

机构：

[1] BIOCHEM THERAPEUT INC,LAVAL,PQ H7V 4A7,CANADA

[2] GLAXO WELLCOME LTD,DEPT VIROL,STEVENAGE SG1 2NY,HERTS,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 15期

关键词：

D O I：

10.1016/0960-894X(95)00294-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

2-Phosphonomethyl-1,3-dioxolane nucleosides containing appropriately linked pyrimidine and purine bases at C-4 position were prepared as biomimetic analogues of antiviral 2',3'-dideoxynucleoside monophosphates. The key coupling intermediate 10 was prepared by a cyclocondensation of diethylacetal 6 and diol 7 followed by hydrolysis and lead tetra-acetate oxidative decarboxylation.

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页码：1741 / 1744

页数：4

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