ELECTROCHEMISTRY OF OMEPRAZOLE, ACTIVE METABOLITES AND A BOUND ENZYME MODEL - POSSIBLE INVOLVEMENT OF ELECTRON-TRANSFER IN ANTIULCER ACTION

被引：10

作者：

AMES, JR ^{[1
]}

KOVACIC, P ^{[1
]}

机构：

[1] UNIV WISCONSIN,DEPT CHEM,MILWAUKEE,WI 53201

来源：

BIOELECTROCHEMISTRY AND BIOENERGETICS | 1992年 / 28卷 / 03期

关键词：

D O I：

10.1016/0302-4598(92)80032-C

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Electrochemical studies were performed with omeprazole, active metabolites and a bound enzyme model. The active metabolites, cyclic sulfenamide and sulfur radical entities, exhibited reduction potentials of -0.3 V and -0.2 V respectively. The value for the bound enzyme model was -0.7 V and that for omeprazole was > -1.4 V. The results lend credence to the hypothesis that electron transfer comprises part of the mode of action in addition to (H+/K+) ATPase inhibition.

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页码：443 / 450

页数：8

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