STEREOSPECIFIC SYNTHESIS OF 4-ALKYLGLUTAMATES AND 4-ALKYLPROLINES

被引：56

作者：

MOODY, CM ^{[1
]}

YOUNG, DW ^{[1
]}

机构：

[1] UNIV SUSSEX,SCH CHEM & MOLEC SCI,BRIGHTON BN1 9QJ,E SUSSEX,ENGLAND

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 39期

关键词：

D O I：

10.1016/0040-4039(94)85381-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Catalytic reduction of the 4-alkylidenepyroglutamate derivatives (3) affords an effective route to (2S,4S)-4-alkylglutamic acids and (2S,4S)-4-alkylprolines. The route has also been used to prepare a 4-alkylpyroglutamic acid derivative which is stereospecifically labelled in the side chain. Synthesis of the (2S,4R)-epimers using cuprate addition has also been investigated.

引用

页码：7277 / 7280

页数：4

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