REGULATION OF RAT MESANGIAL CELL-GROWTH BY DIADENOSINE PHOSPHATES

被引:65
作者
HEIDENREICH, S [1 ]
TEPEL, M [1 ]
SCHLUTER, H [1 ]
HARRACH, B [1 ]
ZIDEK, W [1 ]
机构
[1] UNIV MUNSTER, INST ARTERIOSKLEROSEFORSCH, MED POLIKLIN, D-48129 MUNSTER, GERMANY
关键词
MESANGIAL CELLS; DIADENOSINE PHOSPHATES; PDGF; IGF-1; CYTOSOLIC FREE CA2+;
D O I
10.1172/JCI117992
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The newly recognized human endogenous vasoconstrictive dinucleotides, diadenosine pentaphosphate (AP(5)A) and diadenosine hexaphosphate (AP(6)A), were tested for growth stimulatory effects in rat mesangial cells (MC), Both AP(5)A and AP(6)A stimulated growth in micromolar concentrations, The growth stimulatory effect exceeded that of ATP, alpha,beta-methylene ATP, adenosine 5'-O-(3-thio) triphosphate and UTP, Both diadenosine phosphates potentiated the growth response to platelet-derived growth factor, but not to insulin-like growth factor-1, To further elucidate the site of action in the cell cycle, RNA and protein synthesis were assessed. AP(5) and AP(6)A stimulated protein synthesis, but not RNA formation, Furthermore, both agents increased cytosolic free Ca2+ concentration. It is concluded that AP(5)A and AP(6)A may play a regulatory role in MC growth as progression factors and possibly modify MC proliferation in glomerular disease.
引用
收藏
页码:2862 / 2867
页数:6
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