RECEPTOR-BINDING AT 2 DIFFERENT TEMPERATURES TO DISCRIMINATE AGONIST AND ANTAGONIST BEHAVIOR OF ADENOSINE-A1-RECEPTOR LIGANDS IN RAT-BRAIN

被引：8

作者：

BOREA, PA ^{[1
]}

VARANI, K ^{[1
]}

MALAGUTI, V ^{[1
]}

GILLI, G ^{[1
]}

机构：

[1] UNIV FERRARA,DIPARTMENTO CHIM,I-44100 FERRARA,ITALY

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1991年 / 43卷 / 12期

关键词：

D O I：

10.1111/j.2042-7158.1991.tb03197.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The inhibitory binding constants, K(i), at the adenosine A(l) receptor in rat brain have been measured at 0 and 25-degrees-C for 25 typical ligands. The K(i) ratios at the two temperatures are greater and smaller than unity for adenosine agonists and xanthine antagonists, respectively. These results suggest that two-temperature measurements of in-vitro K(i) constants represent a simple method of discriminating between in-vivo agonistic and antagonistic behaviour of A(l) adenosine receptor ligands.

引用

页码：866 / 868

页数：3

共 8 条

[1] ADENOSINE RECEPTORS IN BRAIN MEMBRANES - BINDING OF N6-CYCLOHEXYL[H-3]ADENOSINE AND 1,3-DIETHYL-8-[H-3]PHENYLXANTHINE [J].