DETECTION OF BK VIRUS-DNA IN NASOPHARYNGEAL ASPIRATES FROM CHILDREN WITH RESPIRATORY-INFECTIONS BUT NOT IN SALIVA FROM IMMUNODEFICIENT AND IMMUNOCOMPETENT ADULT PATIENTS

被引:82
作者
SUNDSFJORD, A
SPEIN, AR
LUCHT, E
FLAEGSTAD, T
SETERNES, OM
TRAAVIK, T
机构
[1] UNIV TROMSO, SCH MED, DEPT VIROL, TROMSO, NORWAY
[2] UNIV TROMSO, SCH MED, DEPT MICROBIOL, TROMSO, NORWAY
[3] UNIV TROMSO, SCH MED, DEPT PEDIAT, TROMSO, NORWAY
[4] NATL INST INFECT CONTROL, DEPT VIROL, STOCKHOLM, SWEDEN
[5] KAROLINSKA INST, HUDDINGE UNIV HOSP, DEPT MICROBIOL, DENT CLIN INFECT DIS, STOCKHOLM, SWEDEN
[6] KAROLINSKA INST, HUDDINGE UNIV HOSP, DEPT ORAL SURG, DENT CLIN INFECT DIS, STOCKHOLM, SWEDEN
关键词
D O I
10.1128/JCM.32.5.1390-1394.1994
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Our understanding of important stages in the pathogenesis of the human polyomavirus BK virus (BKV) and JC virus (JCV) infections is limited. In this contest, nasopharyngeal aspirates from 201 children with respiratory diseases and saliva from 60 human immunodeficiency virus type 1-infected adults and 10 healthy adult controls were collected and analyzed for the presence of BKV and JCV DNA by PCR. Neither BKV nor JCV DNA was detected in the saliva specimens. We demonstrated BKV DNA, but no infectious BKV, in 2 of 201 nasopharyngeal aspirates. Each sample contained one unique rearranged noncoding control region variant of BKV. The results indicate that (i) BKV and JCV are not regularly associated with respiratory infections in children requiring hospitalization, (ii) nasopharyngeal cells are not an important site for primary replication of human polyomavirus BKV and JCV and (iii) the salivary glands and oropharyngeal cells seem not to be involved in BKV and JCV persistence. We propose that for the polyomaviruses BKV and JCV the alimentary tract should be considered as a portal of entrance to the human organism.
引用
收藏
页码:1390 / 1394
页数:5
相关论文
共 58 条
[51]  
TOMINAGA T, 1992, VIROLOGY, V186, P736
[52]   DETECTION OF JC VIRUS-DNA IN PERIPHERAL LYMPHOCYTES FROM PATIENTS WITH AND WITHOUT PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY [J].
TORNATORE, C ;
BERGER, JR ;
HOUFF, SA ;
CURFMAN, B ;
MEYERS, K ;
WINFIELD, D ;
MAJOR, EO .
ANNALS OF NEUROLOGY, 1992, 31 (04) :454-462
[53]  
Ulrich P P, 1993, PCR Methods Appl, V2, P241
[54]  
VALLBRACHT A, 1993, AM J PATHOL, V143, P29
[55]   JC VIRUS-DNA IS PRESENT IN MANY HUMAN BRAIN SAMPLES FROM PATIENTS WITHOUT PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY [J].
WHITE, FA ;
ISHAQ, M ;
STONER, GL ;
FRISQUE, RJ .
JOURNAL OF VIROLOGY, 1992, 66 (10) :5726-5734
[56]   SEQUENCE REARRANGEMENT IN JC VIRUS DNAS MOLECULARLY CLONED FROM IMMUNOSUPPRESSED RENAL-TRANSPLANT PATIENTS [J].
YOGO, Y ;
KITAMURA, T ;
SUGIMOTO, C ;
HARA, K ;
IIDA, T ;
TAGUCHI, F ;
TAJIMA, A ;
KAWABE, K ;
ASO, Y .
JOURNAL OF VIROLOGY, 1991, 65 (05) :2422-2428
[57]  
YOSHIIKE K, 1986, PAPOVAVIRIDAE, V1, P295
[58]  
1987, MORBID MORTAL WE S15, V36, pS3