FIRST LINE TARGETED RADIOTHERAPY, A NEW CONCEPT IN THE TREATMENT OF ADVANCED-STAGE NEUROBLASTOMA

被引:57
作者
DEKRAKER, J
HOEFNAGEL, CA
CARON, H
OLMOS, RAV
ZSIROS, J
HEIJ, HA
VOUTE, PA
机构
[1] UNIV AMSTERDAM,ACAD MED CTR,EMMA KINDERZIEKENHUIS,DEPT PAEDIAT SURG,1100 DE AMSTERDAM,NETHERLANDS
[2] UNIV AMSTERDAM,ACAD MED CTR,EMMA KINDERZIEKENHUIS,DEPT PAEDIAT HAEMATOL ONCOL,1100 DE AMSTERDAM,NETHERLANDS
[3] NETHERLANDS CANC INST,DEPT NUCL MED,AMSTERDAM,NETHERLANDS
关键词
I-131] METAIODOBENZYLGUANIDINE; NEUROBLASTOMA; TARGETED RADIOTHERAPY; PEDIATRIC;
D O I
10.1016/0959-8049(95)00063-O
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
33 previously untreated advanced stage neuroblastoma patients were treated with [I-131] meta-iodobenzylguanidine (MIBG). The number of treatments varied between 2 and 7 per patient (mean 3). Toxicity was seldom severe. Only thrombocytopenia WHO-grade 4 was noticed. Response was documented before surgery for the primary tumour was performed. There was one complete response (CR), 18 partial responses (PR), 11 had stable disease (SD) and 3 had progressive disease (PD). After MIBG therapy and surgery, 12 of 33 patients achieved a CR. This approach is feasible, comparable to multidrug chemotherapy in efficacy and less toxic. Long term results are not known yet.
引用
收藏
页码:600 / 602
页数:3
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