FIRST LINE TARGETED RADIOTHERAPY, A NEW CONCEPT IN THE TREATMENT OF ADVANCED-STAGE NEUROBLASTOMA

被引：57

作者：

DEKRAKER, J

HOEFNAGEL, CA

CARON, H

OLMOS, RAV

ZSIROS, J

HEIJ, HA

VOUTE, PA

机构：

[1] UNIV AMSTERDAM,ACAD MED CTR,EMMA KINDERZIEKENHUIS,DEPT PAEDIAT SURG,1100 DE AMSTERDAM,NETHERLANDS

[2] UNIV AMSTERDAM,ACAD MED CTR,EMMA KINDERZIEKENHUIS,DEPT PAEDIAT HAEMATOL ONCOL,1100 DE AMSTERDAM,NETHERLANDS

[3] NETHERLANDS CANC INST,DEPT NUCL MED,AMSTERDAM,NETHERLANDS

来源：

EUROPEAN JOURNAL OF CANCER | 1995年 / 31A卷 / 04期

关键词：

I-131] METAIODOBENZYLGUANIDINE; NEUROBLASTOMA; TARGETED RADIOTHERAPY; PEDIATRIC;

D O I：

10.1016/0959-8049(95)00063-O

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

33 previously untreated advanced stage neuroblastoma patients were treated with [I-131] meta-iodobenzylguanidine (MIBG). The number of treatments varied between 2 and 7 per patient (mean 3). Toxicity was seldom severe. Only thrombocytopenia WHO-grade 4 was noticed. Response was documented before surgery for the primary tumour was performed. There was one complete response (CR), 18 partial responses (PR), 11 had stable disease (SD) and 3 had progressive disease (PD). After MIBG therapy and surgery, 12 of 33 patients achieved a CR. This approach is feasible, comparable to multidrug chemotherapy in efficacy and less toxic. Long term results are not known yet.

引用

页码：600 / 602

页数：3

共 13 条

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