GENE DUPLICATION AND CONCERTED EVOLUTION OF THE GPDH LOCUS IN NATURAL-POPULATIONS OF DROSOPHILA-MELANOGASTER

被引:7
作者
KUSAKABE, S
BABA, H
KOGA, A
BEWLEY, GC
MUKAI, T
机构
[1] KYUSHU UNIV 33, FAC SCI, DEPT BIOL, FUKUOKA 812, JAPAN
[2] N CAROLINA STATE UNIV, DEPT GENET, RALEIGH, NC 27695 USA
关键词
D O I
10.1098/rspb.1990.0119
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The sn-glycerol-3-phosphate dehydrogenase (GPDH, EC 1, 1, 1, 8) locus of Drosophila melanogaster is polymorphic with respect to the number of tandemly duplicated genes in natural populations. The duplicated genes were cloned and the nucleotide sequences were determined. The duplication deletes both the first and second exons and has a size of 4500 b.p. The fact that there is no sequence variation at the junction point of the duplicated units among strains suggests a single origin for the duplication event. Comparison of the nucleotide sequences among the duplicates indicates that the frequent transfer of genetic information occurs from one to the other of the duplicates on the same chromosome either by gene conversion or by unequal crossing over. Because the GPDH duplication is partial and therefore a kind of pseudogene, the observed polymorphism of the number of tandemly duplicated GPDH genes appears to have been driven mainly by random genetic drift.
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收藏
页码:157 / 162
页数:6
相关论文
共 33 条
[11]   DIDEOXY SEQUENCING METHOD USING DENATURED PLASMID TEMPLATES [J].
HATTORI, M ;
SAKAKI, Y .
ANALYTICAL BIOCHEMISTRY, 1986, 152 (02) :232-238
[12]   TOPOLOGY AND FORMATION OF TRIPLE-STRANDED H-DNA [J].
HTUN, H ;
DAHLBERG, JE .
SCIENCE, 1989, 243 (4898) :1571-1576
[13]   NUCLEOTIDE-SEQUENCE OF AN UNEQUAL SISTER CHROMATID EXCHANGE SITE IN A MOUSE MYELOMA CELL-LINE [J].
KATZENBERG, DR ;
TILLEY, SA ;
BIRSHTEIN, BK .
MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (03) :1324-1326
[14]   THE NEUTRAL THEORY OF MOLECULAR EVOLUTION AND THE WORLD VIEW OF THE NEUTRALISTS [J].
KIMURA, M .
GENOME, 1989, 31 (01) :24-31
[15]  
Kimura M., 1983, NEUTRAL THEORY MOL E
[16]   WIDE-SPREAD POLYMORPHISM OF A TANDEM DUPLICATION IN THE REGION OF THE GLYCEROL-3-PHOSPHATE DEHYDROGENASE GENE IN DROSOPHILA-MELANOGASTER [J].
KOGA, A ;
KUSAKABE, S ;
TAJIMA, F ;
HARADA, K ;
BEWLEY, GC ;
MUKAI, T .
PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES, 1988, 64 (01) :9-12
[17]   NUCLEOTIDE POLYMORPHISM AT THE ALCOHOL-DEHYDROGENASE LOCUS OF DROSOPHILA-MELANOGASTER [J].
KREITMAN, M .
NATURE, 1983, 304 (5925) :412-417
[18]   DRIFTING POLYMORPHISM OF THE NUMBER OF MULTIPLICATION AT THE GLYCEROL-3-PHOSPHATE DEHYDROGENASE LOCUS IN NATURAL-POPULATIONS OF DROSOPHILA-MELANOGASTER [J].
KUSAKABE, S ;
TAKANO, T ;
MUKAI, T .
PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES, 1989, 65 (07) :153-155
[19]  
LACHAISE D, 1988, EVOL BIOL, V22, P159
[20]  
LINDSLEY D, 1969, CARNEGIE I PUBLICATI, V627