STEREOSELECTIVE HYDROLYSIS OF SUBSTITUTED CYCLOPROPANEDICARBOXYLATES WITH PIG-LIVER ESTERASE

被引：34

作者：

WALSER, P ^{[1
]}

RENOLD, P ^{[1
]}

NGOKA, V ^{[1
]}

HOSSEINZADEH, F ^{[1
]}

TAMM, C ^{[1
]}

机构：

[1] UNIV BASEL,INST ORGAN CHEM,ST JOHANNS RING 19,CH-4056 BASEL,SWITZERLAND

来源：

HELVETICA CHIMICA ACTA | 1991年 / 74卷 / 08期

关键词：

D O I：

10.1002/hlca.19910740832

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The hydrolysis of the meso-cyclopropane-1,2-dicarboxylates 1a-3a, 4, 5a, 6a, and 9, containing various substituents at C(3), and of the rac-3-phenylcyclopropane-1,2-dicarboxylates 7a, 8a, and 10 with pig liver esterase (PLE) is described. The stereoselectivity and absolute configurations of the products were determined. An interpretation of results was attempted on the basis of a recent active-site model for PLE.

引用

页码：1941 / 1952

页数：12

共 43 条

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