Skin mucus from Salmo gairdneri contains some molecules (probably protein-bound sulfhydryl groups) able to reduce hexavalent chromium (Cr-VI). Results suggest also that fish slime layer can markedly decrease the Cr(VI) penetration-rate in animal tissues. For these reasons, mucus is regarded as a protective barrier against Cr(VI) pollution, especially during occasional and short lasting exposures to metal. © 1990.