HUMAN RHINOVIRUS-14 COMPLEXED WITH ANTIVIRAL COMPOUND R-61837

被引：54

作者：

CHAPMAN, MS

MINOR, I

ROSSMANN, MG

DIANA, GD

ANDRIES, K

机构：

[1] PURDUE UNIV,DEPT BIOL SCI,W LAFAYETTE,IN 47907

[2] STERLING RES GRP,MED CHEM,RENSSELAER,NY 12144

[3] JANSSEN RES FDN,DEPT VIROL,B-2340 BEERSE,BELGIUM

来源：

JOURNAL OF MOLECULAR BIOLOGY | 1991年 / 217卷 / 03期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

D O I：

10.1016/0022-2836(91)90749-V

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The binding of the antirhinoviral agent R 61837 to human rhinovirus 14 has been examined by X-ray crystallographic methods. The compound R 61837 binds in the same pocket (underneath the canyon floor) as the "WIN" antirhinoviral agents. It does not penetrate as far into the pocket but causes similar conformational changes in the virus capsid. The movement of residues 1217 to 1221 of viral protein 1 (in the "FMDV loop") is more pronounced for R 61837 than for WIN compounds. Although both R 61837 and WIN antiviral agents partially fill the same hydrophobic pocket, atomic binding interactions differ, showing that considerable diversity in the nature of antiviral agents is possible. © 1991.

引用

页码：455 / 463

页数：9