SYNTHESIS AND BIOLOGICAL-ACTIVITY OF ACYCLIC ANALOGS OF NOJIRIMYCIN

被引：20

作者：

FOWLER, PA

HAINES, AH

TAYLOR, RJK

CHRYSTAL, EJT

GRAVESTOCK, MB

机构：

[1] UNIV E ANGLIA, SCH CHEM SCI, NORWICH NR4 7TJ, NORFOLK, ENGLAND

[2] ZENECA AGROCHEM, JEALOTTS HILL RES STN, BRACKNELL RG12 6EY, BERKS, ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1994年 / 16期

关键词：

D O I：

10.1039/p19940002229

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of acyclic compounds has been prepared which comprises compounds that mimic key structural elements of nojirimycin 1 and 1-deoxynojirimycin 2, both of which are highly effective glucosidase inhibitors, in order to ascertain if similar biological activity can be obtained with simpler structures. All of the compounds are competitive inhibitors of yeast alpha-glucosidase. with varying degrees of effectiveness, but none of them, in contrast to 1-deoxynojirimycin 2, show significant anti-HIV activity.

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页码：2229 / 2235

页数：7

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