ANTIMICROBIAL CONSTITUENTS OF RHUS-GLABRA

被引:97
作者
SAXENA, G [1 ]
MCCUTCHEON, AR [1 ]
FARMER, S [1 ]
TOWERS, GHN [1 ]
HANCOCK, REW [1 ]
机构
[1] UNIV BRITISH COLUMBIA,DEPT MICROBIOL,VANCOUVER V6T 1Z3,BC,CANADA
基金
加拿大自然科学与工程研究理事会;
关键词
RHUS GLABRA L; ANACARDIACEAE; ANTIMICROBIAL; METHYL ESTER OF 3,4,5-TRIHYDROXYBENZOIC ACID (METHYL GALLATE); 4-METHOXY-3,5-DIHYDROXYBENZOIC ACID; GALLIC ACID;
D O I
10.1016/0378-8741(94)90102-3
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
The antimicrobial activity of the methanol extract and isolated constituents of Rhus glabra (Anacardiaceae), a species used in folk medicine by North American native people, was evaluated against 11 microorganisms, including grampositive and gram-negative bacteria. The extract was subsequently fractionated and monitored by bioassays leading to the isolation of three antibacterial compounds, the methyl ester of 3,4,5-trihydroxybenzoic acid (methyl gallate) (minimal inhibition concentration (MIC) 12.5 mu g/ml), 4-methoxy-3,5-dihydroxybenzoic acid (MIC 25 mu g/ml) and gallic acid (MIC > 1000 mu g/ml). The first two compounds are reported here for the first time from Rhus glabra. Their structures were established using spectroscopic and chemical methods.
引用
收藏
页码:95 / 99
页数:5
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