EFFECTS OF LOCALIZED BENDING ON DNA SUPERCOILING

被引：45

作者：

YANG, Y ^{[1
]}

WESTCOTT, TP ^{[1
]}

PEDERSEN, SC ^{[1
]}

TOBIAS, I ^{[1
]}

OLSON, WK ^{[1
]}

机构：

[1] RUTGERS STATE UNIV,DEPT CHEM,NEW BRUNSWICK,NJ 08903

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1995年 / 20卷 / 08期

关键词：

D O I：

10.1016/S0968-0004(00)89058-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The DNA double helix is straight only in the idealized case, In reality, it bends, twists and stretches in response to local base sequence and to specific interactions with proteins and other bound ligands, Naturally occurring bends appear to promote the assembly of nucleosomes, and in some cases can effectively replace regulatory DNA-binding proteins in vivo. Recently, a computational method known as 'finite element analysis', which is used routinely by engineers to analyse the stability of buildings and bridges, has been applied to the quantitative assessment of natural curvature in supercoiled DNA structures, providing new insight into the relationship between local, sequence-dependent features and the overall topology of these chains.

引用

页码：313 / 319

页数：7

共 44 条

[31] THE DEPENDENCE OF DNA TERTIARY STRUCTURE ON END CONDITIONS - THEORY AND IMPLICATIONS FOR TOPOLOGICAL TRANSITIONS [J].