CYTOKINES IN CLINICAL AND EXPERIMENTAL TRANSPLANTATION

被引：18

作者：

VOSSEN, ACTM ^{[1
]}

SAVELKOUL, HFJ ^{[1
]}

机构：

[1] ERASMUS UNIV ROTTERDAM, DEPT IMMUNOL, 3000 DR ROTTERDAM, NETHERLANDS

来源：

MEDIATORS OF INFLAMMATION | 1994年 / 3卷 / 06期

关键词：

CYTOKINES; GRAFT REJECTION; MONOCLONAL ANTIBODY TREATMENT; TH1-TH2; SUBSETS; TOLERANCE;

D O I：

10.1155/S0962935194000566

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

ALLOGRAFT rejection is a complex process, which requires interactions between different cell types and a variety of soluble factors, such as cytokines. In this review we discuss the role of cytokines in the induction and effector phases of the rejection process and in the induction and maintenance of allospecific graft tolerance. Furthermore, we discuss the feasibility of clinical graft function monitoring by measuring cytokines and the possibilities for intervention in the cytokine network in order to inhibit graft rejection and eventually obtain graft acceptance.

引用

页码：403 / 410

页数：8

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