DECREASED EXPRESSION OF PROSTATIC SECRETORY PROTEIN PSP94 IN PROSTATE-CANCER

被引：24

作者：

LIU, AY

BRADNER, RC

VESSELLA, RL

机构：

[1] SPECIALTY LABS INC,SANTA MONICA,CA

[2] UNIV WASHINGTON,MED CTR,DEPT UROL,SEATTLE,WA 98195

来源：

CANCER LETTERS | 1993年 / 74卷 / 1-2期

关键词：

SUBTRACTIVE CDNA; PSP94; ANTISERUM TO PSP94;

D O I：

10.1016/0304-3835(93)90049-F

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

cDNA libraries were generated from the prostate gland tissue obtained from a normal donor and from a patient with prostate cancer. Subtractive cDNA cloning was used to identify phenotype-specific cDNA sequences from both normal and cancerous prostate tissue. One clone, pN44, isolated from normal prostate tissue, codes for the prostate protein PSP94, expression of which appeared to be down-regulated in the cancerous cells. Rabbit antisera against PSP94 were generated, and these antisera can be used to detect PSP94 in urine. Two other clones, pN23a and pN141f, were also found to be down-regulated.

引用

页码：91 / 99

页数：9

共 28 条

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