EFFECT OF HYPERCALCEMIA ON RENAL SYMPATHETIC NERVOUS-SYSTEM ACTIVITY

被引:2
作者
LIU, CL [1 ]
BIGAZZI, R [1 ]
BALLARD, J [1 ]
CAMPESE, VM [1 ]
机构
[1] UNIV SO CALIF, LOS ANGELES CTY MED CTR,SCH MED,DEPT MED, DIV NEPHROL,2025 ZONAL AVE, LOS ANGELES, CA 90033 USA
关键词
HYPERCALCEMIA; RENAL SYMPATHETIC NERVE ACTIVITY; NATRIURESIS; RENAL DENERVATION; ALPHA-METHYLTYROSINE;
D O I
10.1159/000168423
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Since calcium plays a modulatory role in the activity of the sympathetic nervous system (SNS), in these studies, we have tested the hypothesis that hypercalcemia may alter renal SNS activity, and, consequently, renal function. Acute hypercalcemia was induced in Sprague-Dawley rats by infusion of calcium 30 mg/kg/2 h in 0.45 % saline. A control group of rats received only 0.45% saline. Two more groups of rats received either calcium or 0.45% saline 7-10 days after total renal denervation. Calcium infusion increased serum calcium by 1.8 +/- 0.23 mg/dl in rats with intact renal nerves and by 2.7 +/- 0.48 mg/dl in renal denervated rats. Mean arterial pressure and inulin clearance did not change during calcium or 0.45% saline in rats with intact renal nerves. Renal sympathetic nerve activity (RSNA) decreased by 44% in rats infused with calcium, but it did not change in control animals. Calcium caused a significantly greater rise in urine volume, sodium excretion and fractional excretion of sodium than the infusion of 0.45 % saline. Rats with renal denervation manifested greater baseline urine volume, sodium excretion and fractional excretion of sodium than rats with intact renal nerves. Infusion of calcium, however, caused no further rise in urine sodium excretion in these animals. alpha-Methyltyrosine, an inhibitor of norepinephrine (NE) synthesis, also increased natriuresis in rats. Calcium reduced by 27% the NE content in the kidney but not in the heart. Methyltyrosine, on the other hand. reduced NE content in both the heart and the kidney. These data demonstrate that acute hypercalcemia inhibits RSNA and increases diuresis and natriuresis in the absence of any change in blood pressure or in glomerular filtration rate.
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页码:86 / 93
页数:8
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[51]   EFFECT OF INTRAVENOUS CALCIUM SALTS ON RENAL EXCRETION IN THE DOG [J].
WOLF, AV ;
BALL, SM .
AMERICAN JOURNAL OF PHYSIOLOGY, 1949, 158 (02) :205-217