MELANOSTATIN, A NEW MELANIN SYNTHESIS INHIBITOR - PRODUCTION, ISOLATION, CHEMICAL-PROPERTIES, STRUCTURE AND BIOLOGICAL-ACTIVITY

被引：33

作者：

ISHIHARA, Y

OKA, M

TSUNAKAWA, M

TOMITA, K

HATORI, M

YAMAMOTO, H

KAMEI, H

MIYAKI, T

KONISHI, M

OKI, T

机构：

[1] Bristol-Myers Squibb Research Institute, Meguro-ku, Tokyo 153

来源：

JOURNAL OF ANTIBIOTICS | 1991年 / 44卷 / 01期

关键词：

D O I：

10.7164/antibiotics.44.25

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Melanostatin, a new antibiotic with melanin synthesis inhibitory activity, was isolated from the fermentation broth of Streptomyces clavifer No. N924-2. Its structure was determined by spectral analysis and degradation experiments. Melanostatin strongly inhibited melanin formation in Streptomyces bikiniensis NRRL B-1049 and B16 melanoma cells.

引用

页码：25 / 32

页数：8

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