SYNTHESIS, STEREOCHEMISTRY, AND BIOLOGICAL PROPERTIES OF THE DEPIGMENTING AGENTS, MELANOSTATIN, FELDAMYCIN AND ANALOGS

被引：17

作者：

IMAE, K

KAMACHI, H

YAMASHITA, H

OKITA, T

OKUYAMA, S

TSUNO, T

YAMASAKI, T

SAWADA, Y

OHBAYASHI, M

NAITO, T

OKI, T

机构：

[1] Bristol-Myers Squibb Research Institute, Meguro-ku, Tokyo 153

来源：

JOURNAL OF ANTIBIOTICS | 1991年 / 44卷 / 01期

关键词：

ACID; DERIVATIVES; FR900490; FUNGUS;

D O I：

10.7164/antibiotics.44.76

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Syntheses of melanostatin and feldamycin have been completed from L-serine and L-theronine, respectively, and the configuration of unknown asymmetric carbons determined. Feldamycin analogs have also been prepared and the L-tryptophyl analog was the most potent in the depigmentation of Streptomyces bikiniensis and B16 melanoma cells.

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收藏

页码：76 / 85

页数：10

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