Mash-1 is expressed during ROD photoreceptor differentiation and binds and E-box, E(opsin-1) in the rat opsin gene

被引：27

作者：

Ahmad, I ^{[1
]}

机构：

[1] UNIV NEBRASKA,MED CTR,DEPT OPHTHALMOL,OMAHA,NE 68198

来源：

DEVELOPMENTAL BRAIN RESEARCH | 1995年 / 90卷 / 1-2期

关键词：

Mash-1; bHLH protein; retina; neurogenesis; photoreceptor; opsin;

D O I：

10.1016/0165-3806(96)83500-0

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

It has been shown previously that the transcription factor Mash-1 plays a significant role in mammalian neurogenesis. In the present study we show that Mash-1 is expressed during rat retinal development and that it interacts specifically with an E-box identified in the promoter of the opsin gene during rod photoreceptor differentiation. We propose that opsin may be one of the downstream neuronal genes regulated by Mash-1 during neurogenesis in the central nervous system.

引用

页码：184 / 189

页数：6