A NEW FLUORENE-DERIVED ANCHOR FOR SOLID-PHASE SYNTHESIS OF PROTECTED PEPTIDES

被引：21

作者：

RABANAL, F ^{[1
]}

GIRALT, E ^{[1
]}

ALBERICIO, F ^{[1
]}

机构：

[1] UNIV BARCELONA,FAC QUIM,DEPT QUIM ORGAN,E-08028 BARCELONA,SPAIN

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 13期

关键词：

BASE-LABILE HANDLE; CONVERGENT SOLID-PHASE PEPTIDE SYNTHESIS; PROTECTED PEPTIDES;

D O I：

10.1016/S0040-4039(00)91730-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-[9-(hydroxymethyl)-2-fluorenyl] succinamic acid may be used as an anchoring linkage for the preparation of protected peptide segments in combination with Boc/Bzl1 protection scheme. The new handle proved to be stable to the usual conditions of solid-phase peptide synthesis and gave the protected peptide in high yields and purities by treatment with piperidine or morpholine.

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页码：1775 / 1778

页数：4

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