CATIONIC AND SECRETORY EFFECTS OF BPDZ-44 AND DIAZOXIDE IN RAT PANCREATIC-ISLETS

被引：13

作者：

ANTOINE, MH

PIROTTE, B

HERMANN, M

DETULLIO, P

DELARGE, J

HERCHUELZ, A

LEBRUN, P

机构：

[1] FREE UNIV BRUSSELS, SCH MED, PHARMACOL LAB, B-1070 BRUSSELS, BELGIUM

[2] UNIV LIEGE, DEPT MED CHEM, LIEGE, BELGIUM

来源：

EXPERIENTIA | 1994年 / 50卷 / 09期

关键词：

BPDZ; 44; DIAZOXIDE; RB-86/CA-45; FLUXES; INSULIN RELEASE; RAT PANCREATIC ISLETS;

D O I：

10.1007/BF01956464

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The present study aimed at comparing the effects of low concentrations of BPDZ 44, a new pyridothia-diazine derivative, and diazoxide on Rb-86 outflow, Ca-45 outflow, Ca-45 uptake and insulin release from rat pancreatic islets. Both drugs caused similar modifications, but the effects of BPDZ 44 on the cationic and secretory events were much more marked than those of diazoxide. It is suggested that BPDZ 44 could be valuable tool for further studies of the K-ATP channels.

引用

页码：830 / 832

页数：3

共 7 条

[1] SODIUM-NITROPRUSSIDE INHIBITS GLUCOSE-INDUCED INSULIN RELEASE BY ACTIVATING ATP-SENSITIVE K+ CHANNELS [J].