K+ CHANNEL OPENERS AND INSULIN RELEASE

被引：31

作者：

LEBRUN, P

ANTOINE, MH

HERCHUELZ, A

机构：

[1] Laboratory of Pharmacology - Brussels Free University - School of Medicine, B-1070 Brussels

来源：

LIFE SCIENCES | 1992年 / 51卷 / 11期

关键词：

D O I：

10.1016/0024-3205(92)90606-P

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Recent in vivo and in vitro experiments suggested that the smooth muscle relaxation mediated by diverse pharmacologic agents resulted from K+ channel opening. Pinacidil, cromakalim, nicorandil, RP 49356, minoxidil sulfate and diazoxide belong to this new group of smooth muscle relaxants : the "K+ channel openers". Because modifications in the K+ permeability are known to represent a critical event in the insulin-releasing process, numerous studies have been performed in order to examine the putative effects of K+ channel openers on B-cell function. The aim of the present review is to summarize these experimental data which are sometimes divergent.

引用

页码：795 / 806

页数：12

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