THE TISSUE RENIN-ANGIOTENSIN SYSTEMS IN CARDIOVASCULAR-DISEASE

被引：66

作者：

PAUL, M

BACHMANN, J

GANTEN, D

机构：

[1] UNIV HEIDELBERG,DEPT PHARMACOL,W-6900 HEIDELBERG,GERMANY

[2] MAX DELBRUCK CTR MOLEC MED,O-1115 BERLIN,GERMANY

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 1992年 / 2卷 / 03期

关键词：

D O I：

10.1016/1050-1738(92)90013-I

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The renin-angiotensin system, in its classic definition, is known as an endocrine system that exerts its actions through the effector peptide, angiotensin II, in various organs to act as a vasoconstrictor and a regulator of salt and volume homeostasis. The availability of more sensitive methods to study the biochemistry and pharmacology as well as the molecular biology of the RAS has expanded our knowledge of the system and provided new perspectives of autocrine and paracrine functions of the RAS in cardiovascular regulation. One of the more exciting of these recently described actions is the possible involvement of the RAS in the adaptive processes related to cardiovascular hypertrophy and angiogenesis.

引用

页码：94 / 99

页数：6