EVALUATION OF PROGNOSTIC FACTORS AND SEQUENTIAL COMBINATION CHEMOTHERAPY WITH DOXORUBICIN FOR CANINE LYMPHOMA

被引：189

作者：

KELLER, ET ^{[1
]}

MACEWEN, EG ^{[1
]}

ROSENTHAL, RC ^{[1
]}

HELFAND, SC ^{[1
]}

FOX, LE ^{[1
]}

机构：

[1] UNIV WISCONSIN,SCH VET MED,DEPT MED SCI,2015 LINDEN DR,MADISON,WI 53706

来源：

JOURNAL OF VETERINARY INTERNAL MEDICINE | 1993年 / 7卷 / 05期

关键词：

D O I：

10.1111/j.1939-1676.1993.tb01021.x

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Fifty‐five dogs with lymphoma were treated using a doxorubicin‐based sequential combination chemotherapy protocol. Complete response, partial response, and no response were seen in 46, 4, and 5 dogs, respectively. The overall median remission duration and survival times were 36 and 51 weeks, respectively. Age, sex, weight, World Health Organization stage, World Health Organization substage (i.e., a = not ill, b = ill), serum calcium concentration, blood urea nitrogen concentration, breed, and protocol alteration secondary to toxicity were evaluated for prognostic significance. Univariate analysis of prognostic factors identified sex, World Health Organization substage, and serum calcium as statistically significant (P≤ .05) variables for both survival and remission duration. Upon multivariate analysis, only substage (P= .036) was a significant prognostic factor for remission duration, whereas, both substage (P= .006) and sex (P= .005) were significant prognostic factors for survival. (Journal of Veterinary Internal Medicine 1993; 7:289–295. Copyright © 1993 by the American College of Veterinary Internal Medicine.) Copyright © 1993, Wiley Blackwell. All rights reserved

引用

页码：289 / 295

页数：7

共 24 条

[11]

van Vechten M., Helfand SC, Jeglum KA, Treatment of relapsed canine lymphoma with doxorubicin and dacarbazine, J Vet Int Med, 4, pp. 187-191, (1990)

[12]

Jeglum KA, Young KM, Barnsley K., Et al., Chemotherapy versus chemotherapy with intralymphatic tumor cell vaccine in canine lymphoma, Cancer, 61, pp. 2042-2050, (1988)

[13]

Cotter SM, Goldstein MA., Comparison of two protocols for maintenance of remission in dogs with lymphoma, J Am Anim Hosp Assoc, 23, pp. 495-499, (1987)

[14]

Stone MS, Goldstein MA, Cotter SM., Comparison of two protocols for induction of remission in dogs with lymphoma, J Am Anim Hosp Assoc, 27, pp. 315-321, (1991)

[15]

Ogilvie GK, Vail DM, Klein MK, Et al., Weekly administration of low‐dose doxorubicin for treatment of malignant lymphoma in dogs, J Am Vet Med Assoc, 198, pp. 1762-1764, (1991)

[16]

Rosenthal RC, MacEwen EG., Treatment of lymphoma in dogs, J Am Vet Med Assoc, 196, pp. 774-781, (1990)

[17]

(1980)

[18]

Couto CG., Canine extranodal lymphomas, Current Veterinary Therapy IX: Small animal practice, pp. 473-477, (1986)

[19]

Dawson-Sanders B., Trapp RG., Basic and clinical biostatistics, pp. 142-160, (1990)

[20]

Dunn OJ., Basic statistics: A primer for the biomedical sciences, pp. 122-135, (1983)

← 1 2 3 →