IMMUNORECOGNITION OF CHONDROCYTES IN ARTICULAR-CARTILAGE ACTIVATED BY SYNOVIAL INTERLEUKIN-1

被引：14

作者：

DAVIES, ME

HORNER, A

DINGLE, JT

机构：

[1] Tissue Physiology Department, Strangeways Research Laboratory, Worts' Causeway, Cambridge

来源：

CONNECTIVE TISSUE RESEARCH | 1991年 / 25卷 / 3-4期

关键词：

CHONDROCYTES; ARTICULAR CARTILAGE; INTERLEUKIN-1; SYNOVIUM;

D O I：

10.3109/03008209109029160

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A polyclonal antiserum which recognizes surface epitopes on IL1-activated pig chondrocytes has been used to immunolocalize chondrocytes responding to IL1 produced during co-culture of pig synovium and articular cartilage. Activation of the chondrocytes by the cytokine was restricted to the articular and subarticular region of the cartilage adjacent to the synovium. Chondrocyte activation was also seen when human rheumatoid synovium was co-cultured with the cartilage. The presence of ILl in some synovial cells was confirmed by immunolocalization using antisera specific for ILlα and ILlβ. © 1991 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：243 / &

共 21 条

[1] DIFFERENCES BETWEEN SUB-POPULATIONS OF CULTURED BOVINE ARTICULAR CHONDROCYTES .1. MORPHOLOGY AND CARTILAGE MATRIX PRODUCTION [J].