STUDY OF STEREO-REQUIREMENTS OF SUBSTANCE-P BINDING TO NK1 RECEPTORS USING ANALOGS WITH SYSTEMATIC D-AMINO-ACID REPLACEMENTS

被引：20

作者：

WANG, JX

DIPASQUALE, AJ

BRAY, AM

MAEJI, NJ

GEYSEN, HM

机构：

[1] Chiron Mimotopes Pty. Ltd., Clayton, Vic. 3168

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 03期

关键词：

D O I：

10.1016/S0960-894X(01)80230-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A total of 512 stereoisomers of substance P, generated by systematic D-amino acid replacements, were synthesised by the multipin technique and their binding potencies to central NK1 receptors assessed. These results provide a comprehensive database for molecular modelling and drug design.

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页码：451 / 456

页数：6

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