HIGH-RESOLUTION DETERMINATION OF PM-147 IN URINE USING DYNAMIC ION-EXCHANGE CHROMATOGRAPHY

被引：8

作者：

ELCHUK, S

LUCY, CA

BURNS, KI

机构：

[1] UNIV CALGARY,DEPT CHEM,2500 UNIV DR NW,CALGARY T2N 1N4,ALBERTA,CANADA

[2] ATOM ENERGY CANADA LTD,CHALK RIVER NUCL LABS,GEN CHEM BRANCH,CHALK RIVER K0J 1J0,ONTARIO,CANADA

来源：

ANALYTICAL CHEMISTRY | 1992年 / 64卷 / 20期

关键词：

D O I：

10.1021/ac00044a007

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A procedure has been developed for measuring Pm-147 in bioassay samples, based on the separation and preconcentration of Pm-147 from the urine matrix by adsorption onto a conventional cation-exchange column with final separation and purification by HPLC using dynamic ion-exchange chromatography. The concentration of Pm-147 is determined by collecting the appropriate HPLC fraction and measuring the Pm-147 by liquid scintillation counting. The limit of detection is 0.1 Bq (3 fg) Pm-147 based on a 500-mL sample of urine and a counting time of 30 min with a background of 100 cpm. Ten samples can be processed in 1.5-2 days.

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页码：2339 / 2343

页数：5

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