ENDOTHELIN SARAFOTOXIN RECEPTOR INDUCED PHOSPHOINOSITIDE TURNOVER - EFFECTS OF PERTUSSIS AND CHOLERA TOXINS AND OF PHORBOL ESTER

被引：43

作者：

GALRON, R

BDOLAH, A

KLOOG, Y

SOKOLOVSKY, M

机构：

[1] TEL AVIV UNIV,GEORGE S WISE FAC LIFE SCI,DEPT BIOCHEM,NEUROBIOCHEM LAB,IL-69978 TEL AVIV,ISRAEL

[2] TEL AVIV UNIV,GEORGE S WISE FAC LIFE SCI,DEPT ZOOL,IL-69978 TEL AVIV,ISRAEL

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 171卷 / 03期

关键词：

D O I：

10.1016/0006-291X(90)90776-J

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The induction of phosphoinositide hydrolysis (PI) by endothelin/sarafotoxin (ET/SRTX) receptors in rat heart myocytes was investigated by the use of bacterial toxins as well as a phorbol ester. Both pertussis- and choleratoxin enhanced the stimulation of PI hydrolysis. Phorbol ester treatment of the myocytes for short periods distinguished between two types of PI-hydrolysis, the one induced by endothelins and the other by sarafotoxins. The possible mediation of G-protein (s) in the induction by ET/SRTX receptors of PI-hydrolysis is discussed. © 1990.

引用

页码：949 / 954

页数：6

共 19 条

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