ALTERATIONS IN THE POTASSIUM-EVOKED RELEASE OF SUBSTANCE-P FROM THE SPINAL-CORD OF STREPTOZOTOCIN-INDUCED DIABETIC RATS INVITRO

被引：18

作者：

KAMEI, J

OGAWA, Y

OHHASHI, Y

KASUYA, Y

机构：

[1] Department of Pharmacology, School of Pharmacy, Hoshi University, Shinagawa-ku, Tokyo, 142, 4-41

来源：

GENERAL PHARMACOLOGY | 1991年 / 22卷 / 06期

关键词：

D O I：

10.1016/0306-3623(91)90583-R

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The release of SPLI evoked by high levels of K+ (50 mM) from the spinal cord of diabetic rats was greater than in the case of spinal cord from control rats. 2. Morphine (10(-5) M) Significantly inhibited the K+-evoked release of SPLI release in both the groups. However, in spinal cord from diabetic rats, morphine reduced the K+-evoked release of SPLI only to the levels that were observed in material from control rats prior to treatment with morphine. 3. Glucose (20 mM) and dibutyryl cyclic-AMP (10(-4) M) significantly potentiated the K+-evoked release of SPLI in spinal cord from control rats. 4. These findings suggest that excessive release of SPLI from the spinal cord may be associated with the reported abnormalities in nociceptive transmission in diabetic rats, and that excessive release of SPLI may be modulated by levels of glucose and/or cyclic-AMP in the spinal cord.

引用

页码：1093 / 1096

页数：4

共 21 条

[11] COMPARISON OF SELECTIVE AND COMPLETE INHIBITORS OF ENKEPHALIN-DEGRADING ENZYMES ON MORPHINE WITHDRAWAL SYNDROME [J].