VESTIBULAR COMPENSATION AFFECTS ENDOGENOUS PHOSPHORYLATION OF FROG BRAIN PROTEINS

被引：15

作者：

JANSSEN, U ^{[1
]}

RICHTERLANDSBERG, C ^{[1
]}

FLOHR, H ^{[1
]}

机构：

[1] UNIV BREMEN,BRAIN RES INST,W-2800 BREMEN 33,GERMANY

来源：

JOURNAL OF NEUROCHEMISTRY | 1992年 / 58卷 / 01期

关键词：

NEURONAL PLASTICITY; VESTIBULAR COMPENSATION; PHOSPHOPROTEINS; FROG BRAIN; MYELIN BASIC PROTEIN;

D O I：

10.1111/j.1471-4159.1992.tb09277.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of unilateral labyrinthectomy followed by the process of vestibular compensation on the incorporation of radioactive phosphate into frog brain proteins was investigated. Phosphoproteins were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis followed by autoradiography. The present data show that unilateral labyrinthectomy affects the incorporation of P-32 into various frog brain proteins. In particular, the phosphorylation of a 20-kDa protein appeared enhanced during early stages of vestibular compensation (4-12 days). This 20-kDa protein was shown to be immunologically related to myelin basic protein and its phosphorylation was regulated by an endogenous calcium/calmodulin-dependent protein kinase. These data might indicate that in addition to neuronal components, components of glial origin are also involved in biochemical events that lead to functional recovery after neuronal lesions.

引用

页码：65 / 71

页数：7

共 36 条

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