PHARMACOKINETIC MODELING OF DOGFISH SHARK (SQUALUS-ACANTHIAS) - DISTRIBUTION AND URINARY AND BILIARY-EXCRETION OF PHENOL RED AND ITS GLUCURONIDE

被引：38

作者：

BUNGAY, PM

DEDRICK, RL

GUARINO, AM

机构：

[1] NIH, DIV RES SERV, BIOMED ENGN & INSTR BRANCH, BETHESDA, MD 20014 USA

[2] NCI, TOXICOL LAB, BETHESDA, MD 20014 USA

来源：

JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS | 1976年 / 4卷 / 05期

关键词：

D O I：

10.1007/BF01062827

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A flow-limited multicompartment model simulates the distribution and disposition of phenol red in the dogfish [S. acanthias] after i.v. administration. Glucuromide conjugate, as well as parent compound, was found in urine and bile, but not in plasma, kidney or liver tissues. An apparent 4 h lag in phenol red appearance in the gall bladder was simulated using 2 stirred tanks connected in series to represent the bile ducts. The model should faciliate use of the dogfish in pharmacokinetic studies of drugs, environmental contaminants and other xenobiotics.

引用

页码：377 / 388

页数：12