NEUROENDOCRINE EVIDENCE FOR REDUCED SEROTONERGIC NEUROTRANSMISSION DURING HEAVY DRINKING

被引：41

作者：

BALLDIN, J

BERGGREN, U

ENGEL, J

ERIKSSON, M

机构：

[1] UNIV GOTHENBURG,DEPT CLIN NEUROSCI,PSYCHIAT & NEUROCHEM SECT,GOTHENBURG,SWEDEN

[2] GOTHENBURG UNIV,DEPT PHARMACOL,GOTHENBURG,SWEDEN

来源：

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH | 1994年 / 18卷 / 04期

关键词：

FENFLURAMINE; PROLACTIN; TEMPERATURE; ALCOHOL INTAKE;

D O I：

10.1111/j.1530-0277.1994.tb00045.x

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

A fenfluramine (60 mg oral dose) challenge test was performed in 19 male heavy drinkers (mean daily consumption 88 g of pure alcohol). Twelve healthy males served as controls. The prolactin and temperature responses to fenfluramine were significantly reduced in the group of heavy drinkers. The results suggest impaired central serotonergic neurotransmission in alcoholism, possibly involving subsensitivity in various serotonin receptor subtypes.

引用

页码：822 / 825

页数：4

共 21 条

[1]

AMIT Z, 1985, RES ADV NEW PSYCHOPH, P189

[2]

BALLDIN J, 1994, IN PRESS ALCOHOL CLI

[3]

BALLDIN J, 1994, IN PRESS DRUG ALCOHO

[4]

BALLENGER JC, 1979, ARCH GEN PSYCHIAT, V36, P224