NEUROENDOCRINE EVIDENCE FOR REDUCED SEROTONERGIC NEUROTRANSMISSION DURING HEAVY DRINKING

被引：41

作者：

BALLDIN, J

BERGGREN, U

ENGEL, J

ERIKSSON, M

机构：

[1] UNIV GOTHENBURG,DEPT CLIN NEUROSCI,PSYCHIAT & NEUROCHEM SECT,GOTHENBURG,SWEDEN

[2] GOTHENBURG UNIV,DEPT PHARMACOL,GOTHENBURG,SWEDEN

来源：

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH | 1994年 / 18卷 / 04期

关键词：

FENFLURAMINE; PROLACTIN; TEMPERATURE; ALCOHOL INTAKE;

D O I：

10.1111/j.1530-0277.1994.tb00045.x

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

A fenfluramine (60 mg oral dose) challenge test was performed in 19 male heavy drinkers (mean daily consumption 88 g of pure alcohol). Twelve healthy males served as controls. The prolactin and temperature responses to fenfluramine were significantly reduced in the group of heavy drinkers. The results suggest impaired central serotonergic neurotransmission in alcoholism, possibly involving subsensitivity in various serotonin receptor subtypes.

引用

收藏

页码：822 / 825

页数：4

相关论文

共 21 条

[11] SUBTYPES OF SEROTONIN RECEPTORS - BIOCHEMICAL-CHANGES AND PHARMACOLOGICAL CONSEQUENCES [J].

LEONARD, BE .

INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY, 1992, 7 (01) :13-21

[12] HORMONE RESPONSES TO FENFLURAMINE AND PLACEBO CHALLENGE IN ENDOGENOUS-DEPRESSION [J].

LICHTENBERG, P ;

SHAPIRA, B ;

GILLON, D ;

KINDLER, S ;

COOPER, TB ;

NEWMAN, ME ;

LERER, B .

PSYCHIATRY RESEARCH, 1992, 43 (02) :137-146

[13] CORTISOL AND PROLACTIN RESPONSES TO D-FENFLURAMINE IN NONDEPRESSED PATIENTS WITH OBSESSIVE-COMPULSIVE DISORDER - A COMPARISON WITH DEPRESSED AND HEALTHY CONTROLS [J].

LUCEY, JV ;

OKEANE, V ;

BUTCHER, G ;

CLARE, AW ;

DINAN, TG .

BRITISH JOURNAL OF PSYCHIATRY, 1992, 161 :517-521

[14]

MELTZER HY, 1982, SEROTONIN BIOL PSYCH, P117

[15] HORMONAL RESPONSES TO FENFLURAMINE IN DEPRESSED AND CONTROL SUBJECTS [J].

MITCHELL, P ;

SMYTHE, G .

JOURNAL OF AFFECTIVE DISORDERS, 1990, 19 (01) :43-51

[16]

MURPHY DL, 1986, J CLIN PSYCHIAT, V47, P9

[17] THE SEROTONIN UPTAKE INHIBITOR CITALOPRAM ATTENUATES ETHANOL INTAKE [J].

NARANJO, CA ;

SELLERS, EM ;

SULLIVAN, JT ;

WOODLEY, DV ;

KADLEC, K ;

SYKORA, K .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 1987, 41 (03) :266-274

[18] DIFFERENTIAL-EFFECTS OF VIQUALINE ON ALCOHOL INTAKE AND OTHER CONSUMMATORY BEHAVIORS [J].

NARANJO, CA ;

SULLIVAN, JT ;

KADLEC, KE ;

WOODLEYREMUS, DV ;

KENNEDY, G ;

SELLERS, EM .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 1989, 46 (03) :301-309

[19] ZIMELIDINE-INDUCED VARIATIONS IN ALCOHOL INTAKE BY NONDEPRESSED HEAVY DRINKERS [J].

NARANJO, CA ;

SELLERS, EM ;

ROACH, CA ;

WOODLEY, DV ;

SANCHEZCRAIG, M ;

SYKORA, K .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 1984, 35 (03) :374-381

[20] FLUOXETINE DIFFERENTIALLY ALTERS ALCOHOL INTAKE AND OTHER CONSUMMATORY BEHAVIORS IN PROBLEM DRINKERS [J].

NARANJO, CA ;

KADLEC, KE ;

SANHUEZA, P ;

WOODLEYREMUS, D ;

SELLERS, EM .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 1990, 47 (04) :490-498