PKR - A NEW NAME AND NEW ROLES

被引:199
作者
PROUD, CG
机构
[1] Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, BS8 1TD, University Walk
关键词
D O I
10.1016/S0968-0004(00)89025-8
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The double-stranded RNA (dsRNA)-activated protein kinase, now called PKR, was first discovered by virtue of its ability to phosphorylate translation initiation factor elF-2 and inhibit its activity. Recent studies have shown that expression of inactive mutants of PKR in cultured cells causes them to acquire characteristics typical of transformed cells. These and other findings indicate that PKR plays a role in the normal control of cell growth and differentiation. It seems likely that, in addition to elF-2, PKR has other substrates including the protein I-kappa B, which regulates the transcription of certain genes. Indeed, it now seems likely that PKR mediates the regulation of selected genes by dsRNA.
引用
收藏
页码:241 / 246
页数:6
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