TRANSLATIONAL CONTROL OF GCN4 - AN IN-VIVO BAROMETER OF INITIATION-FACTOR ACTIVITY

被引：163

作者：

HINNEBUSCH, AG

机构：

[1] A. G. Hinnebusch is at the Section on Molecular Genetics of Lower Eukaryotes, Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1994年 / 19卷 / 10期

关键词：

D O I：

10.1016/0968-0004(94)90089-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phosphorylation of translation initiation factor-2 (elF-2) is an adaptive mechanism for downregulating protein synthesis under conditions of starvation and stress. The yeast Saccharomyces has evolved a sophisticated means of increasing translation of GCN4 mRNA when elF-2 is phosphorylated, allowing the induction of an important stress-response protein when expression of most other genes is decreasing. Because translation of GCN4 mRNA is so tightly coupled to elF-2 activity, genetic analysis of this system has provided unexpected insights into the regulation of elF-2 and its guanine nucleotide exchange factor, elF-2B.

引用

页码：409 / 414

页数：6

共 36 条

[1] SUPPRESSION OF RIBOSOMAL REINITIATION AT UPSTREAM OPEN READING FRAMES IN AMINO ACID-STARVED CELLS FORMS THE BASIS FOR GCN4 TRANSLATIONAL CONTROL [J].

ABASTADO, JP ;

MILLER, PF ;

JACKSON, BM ;

HINNEBUSCH, AG .

MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (01) :486-496

[2] GUANINE-NUCLEOTIDE EXCHANGE FACTOR FOR EUKARYOTIC TRANSLATION INITIATION FACTOR-II IN SACCHAROMYCES-CEREVISIAE - INTERACTIONS BETWEEN THE ESSENTIAL SUBUNITS GCD2, GCD6, AND GCD7 AND THE REGULATORY SUBUNIT GCN3 [J].

BUSHMAN, JL ;

FOIANI, M ;

CIGAN, AM ;

PADDON, CJ ;

HINNEBUSCH, AG .

MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (08) :4618-4631

[3] EVIDENCE THAT GCD6 AND GCD7, TRANSLATIONAL REGULATORS OF GCN4, ARE SUBUNITS OF THE GUANINE-NUCLEOTIDE EXCHANGE FACTOR FOR EIF-2 IN SACCHAROMYCES-CEREVISIAE [J].

BUSHMAN, JL ;

ASURU, AI ;

MATTS, RL ;

HINNEBUSCH, AG .

MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (03) :1920-1932

[4] HUMAN P68 KINASE EXHIBITS GROWTH SUPPRESSION IN YEAST AND HOMOLOGY TO THE TRANSLATIONAL REGULATOR GCN2 [J].

CHONG, KL ;

FENG, L ;

SCHAPPERT, K ;

MEURS, E ;

DONAHUE, TF ;

FRIESEN, JD ;

HOVANESSIAN, AG ;

WILLIAMS, BRG .

EMBO JOURNAL, 1992, 11 (04) :1553-1562

[5] COMPLEX-FORMATION BY POSITIVE AND NEGATIVE TRANSLATIONAL REGULATORS OF GCN4 [J].

CIGAN, AM ;

FOIANI, M ;

HANNIG, EM ;

HINNEBUSCH, AG .

MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (06) :3217-3228

[6] TRANSFER RNA(IMET) FUNCTIONS IN DIRECTING THE SCANNING RIBOSOME TO THE START SITE OF TRANSLATION [J].

CIGAN, AM ;

FENG, L ;

DONAHUE, TF .

SCIENCE, 1988, 242 (4875) :93-97

[7] YEAST TRANSLATION INITIATION SUPPRESSOR SUI2 ENCODES THE ALPHA-SUBUNIT OF EUKARYOTIC INITIATION FACTOR-II AND SHARES SEQUENCE IDENTITY WITH THE HUMAN ALPHA-SUBUNIT [J].

CIGAN, AM ;

PABICH, EK ;

FENG, L ;

DONAHUE, TF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (08) :2784-2788

[8] A PROTEIN COMPLEX OF TRANSLATIONAL REGULATORS OF GCN4 MESSENGER-RNA IS THE GUANINE NUCLEOTIDE-EXCHANGE FACTOR FOR TRANSLATION INITIATION FACTOR-II IN YEAST [J].

CIGAN, AM ;

BUSHMAN, JL ;

BOAL, TR ;

HINNEBUSCH, AG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (11) :5350-5354

[9] SEQUENCE, STRUCTURAL AND EVOLUTIONARY RELATIONSHIPS BETWEEN CLASS-2 AMINOACYL-TRANSFER RNA-SYNTHETASES [J].

CUSACK, S ;

HARTLEIN, M ;

LEBERMAN, R .

NUCLEIC ACIDS RESEARCH, 1991, 19 (13) :3489-3498

[10] MUTATIONS IN THE GCD7 SUBUNIT OF YEAST GUANINE-NUCLEOTIDE EXCHANGE FACTOR EIF-2B OVERCOME THE INHIBITORY EFFECTS OF PHOSPHORYLATED EIF-2 ON TRANSLATION INITIATION [J].

DEALDANA, CRV ;

HINNEBUSCH, AG .

MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (05) :3208-3222

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