EFFECT OF SCATTER FACTOR AND HEPATOCYTE GROWTH-FACTOR ON MOTILITY AND MORPHOLOGY OF MDCK CELLS

被引：1

作者：

LI, Y

JOSEPH, A

BHARGAVA, MM

ROSEN, EM

NAKAMURA, T

GOLDBERG, I

机构：

[1] LONG ISL JEWISH MED CTR,DEPT RADIAT ONCOL,NEW HYDE PK,NY 11042

[2] YALE UNIV,SCH MED,DEPT THERAPEUT RADIOL,NEW HAVEN,CT 06510

[3] KYUSHU UNIV,FAC SCI,FUKUOKA 812,JAPAN

来源：

IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL | 1992年 / 28A卷 / 05期

关键词：

SCATTER FACTOR; HEPATOCYTE GROWTH FACTOR; CELL MOTILITY; CELL MORPHOLOGY;

D O I：

暂无

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We investigated the effects of human placental scatter factor (hSF), mouse scatter factor (mSF) and recombinant human hepatocyte growth factor (HGF) on motility and morphology of individual Madin-Darby canine kidney cells using a computerized cell tracking system. All three factors increased the velocity of individual cells and the ratio of moving to stationary cells. Similarly, all three factors caused changes in morphologic features of cells, leading to increased area, flatness, and polarity. Increases in area and flatness but not polarity were slightly greater with HGF than with hSF or mSF. These results suggest that SFs and HGF have similar effects on motility and morphology of isolated epithelial cells.

引用

页码：364 / 368

页数：5

共 22 条

[1]

BHARGAVA MM, 1991, CELL MOTILITY FACTOR, P63

[2] IDENTIFICATION OF THE HEPATOCYTE GROWTH-FACTOR RECEPTOR AS THE C-MET PROTOONCOGENE PRODUCT [J].