SEROTONERGIC POTENTIATION OF PHOTIC PHASE-SHIFTS OF THE CIRCADIAN ACTIVITY RHYTHM

被引：57

作者：

REA, MA ^{[1
]}

BARRERA, J ^{[1
]}

GLASS, JD ^{[1
]}

GANNON, RL ^{[1
]}

机构：

[1] KENT STATE UNIV,DEPT BIOL,KENT,OH 44242

来源：

NEUROREPORT | 1995年 / 6卷 / 10期

关键词：

SUPRACHIASMATIC NUCLEI; CIRCADIAN RHYTHM; PHOTIC ENTRAINMENT; SEROTONIN; 5-HT1A RECEPTOR; 5-HT7; RECEPTOR;

D O I：

10.1097/00001756-199507100-00014

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

RECENT evidence suggests that serotonin may function to regulate the sensitivity of the circadian clock to the resetting effect of environmental light. Here we report that systemic administration of NAN-190, a drug that acts at both postsynaptic and somatodendritic serotonin receptors, potentiates light-induced phase shifts by as much as 250%. The effects of the drug are dose-related and are significant at light intensities between 0.2 and 200 lux. It is proposed that drugs with pharmacological properties similar to NAN-190 may prove useful as chronobiologics to adjust the sensitivity of the circadian system to natural 'zeitgebers'.

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页码：1417 / 1420

页数：4

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