A HISTORY OF FRONTAL AND TEMPORAL-LOBE ASPECTS OF THE NEUROPHARMACOLOGY OF SCHIZOPHRENIA

In the past two decades neurobiological research into schizophrenia has seen a shift of emphasis from the dopaminergic pharmacology of subcortical systems to areas of abnormality inferred from direct studies, i.e. frontal cortex and medial temporal lobe. Recent research has tried to integrate morphological abnormalities with neurochemical and pharmacological data. These integrated approaches have uncovered neurochemical systems other than dopamine which are of importance. This approach has led to greater understanding of neurochemical mechanisms associated with these abnormalities and may provide novel approaches for therapeutic intervention.