NER, A NEW MEMBER OF THE GENE FAMILY ENCODING THE HUMAN STEROID-HORMONE NUCLEAR RECEPTOR

被引：122

作者：

SHINAR, DM ^{[1
]}

ENDO, N ^{[1
]}

RUTLEDGE, SJ ^{[1
]}

VOGEL, R ^{[1
]}

RODAN, GA ^{[1
]}

SCHMIDT, A ^{[1
]}

机构：

[1] MERCK SHARP & DOHME LTD,RES LABS,DEPT BONE BIOL & OSTEOPOROSIS RES,W POINT,PA 19486

来源：

GENE | 1994年 / 147卷 / 02期

关键词：

OSTEOSARCOMA; RETINOID; DNA BINDING; SEQUENCE; ORPHAN RECEPTOR;

D O I：

10.1016/0378-1119(94)90080-9

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

NER, a new member of the steroid hormone nuclear receptor (NR)-encoding gene family, was isolated from a human osteosarcoma SAOS/B10 cell line cDNA library. NER codes for a polypeptide of 461 amino acids which contains the conserved sequences of the DNA-binding and ligand-binding domains of typical steroid hormone NR. It has highest homology with the retinoic acid receptors: 55% at the DNA-binding domain and 38-40% at the ligand-binding domain. A single transcript of 2.3 kb was detected in all cells and tissues tested. Although no ligand was identified for NER-I, its wide distribution may indicate that this novel steroid hormone NR may play a basic role in cell function.

引用

页码：273 / 276

页数：4

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